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Aspergilloglutamic peptidase, also called aspergillopepsin II (, ''proctase A'', '' Aspergillus niger acid proteinase A'', ''Aspergillus niger var. macrosporus aspartic proteinase'') is a proteolytic enzyme. The enzyme was previously thought be an aspartic protease, but it was later shown to be an glutamic protease with a catalytic Glu residue at the active site, and was therefore renamed aspergilloglutamic peptidase. Determination of its molecular structure showed it to be a unique two-chain enzyme with a light chain and a heavy chain bound non-covalently with each other. The C-terminal region of the light chain of one molecule binds to the active site cleft of another molecule in the manner of a substrate. This enzyme catalyses the following chemical reaction : Preferential cleavage in B chain of insulin: Asn3-Gln, Gly13-Ala, Tyr26-Thr This enzyme is isolated from ''Aspergillus niger var. macrosporus''. == References == 抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「Aspergillopepsin II」の詳細全文を読む スポンサード リンク
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